{"id":1650,"date":"2025-08-19T13:57:27","date_gmt":"2025-08-19T04:57:27","guid":{"rendered":"https:\/\/lmi.jp\/articles\/?p=1650"},"modified":"2025-11-26T14:26:42","modified_gmt":"2025-11-26T05:26:42","slug":"analysis-of-food-allergy-history-of-patients-who-developed-mild-allergic-transfusion-reactions","status":"publish","type":"post","link":"https:\/\/lmi.jp\/articles\/2025\/08\/19\/analysis-of-food-allergy-history-of-patients-who-developed-mild-allergic-transfusion-reactions\/","title":{"rendered":"Analysis of food allergy history of patients who developed mild allergic transfusion reactions"},"content":{"rendered":"\n

 Katsuhiro Takano<\/strong><\/a>*1<\/sup>, Kazuha Tobo<\/a><\/strong>*2<\/sup>, Hiroshi Nakamura<\/a><\/strong>*2<\/sup>, Toshiaki Shirai<\/a><\/strong>*1<\/sup>, Takako Kobayashi*<\/strong><\/a>3<\/sup>, Yuko Nakajima<\/strong><\/a>*1<\/sup>, Junichi Hara<\/strong><\/a>*1<\/sup>, Kanji Sugita<\/strong><\/a>*4<\/sup>,  Katsue Suzuki-Inoue<\/strong><\/a>*1,5<\/sup><\/p>\n\n\n\n

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\u2003 Cite<\/span><\/span><\/i><\/i><\/span><\/summary>
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Takano K, Tobo K, Nakamura H, Shirai T, Kobayashi T, Nakajima Y, Hara J, Sugita K, Suzuki K. Analysis of food allergy history of patients who developed mild allergic transfusion reactions. Lab Med Int 2025; 4(2): 49-53. doi: 10.51041\/lmi.4.2_49<\/p>\n<\/div><\/details>\n<\/div>\n\n\n\n


Short Communication
Lab Med Int 2025; 4(2): 49-53<\/p>\n\n\n\n

\u2020\u0007Correspondence: Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan. E-mail: katsuei”@”yamanashi.ac.jp
Received March 6, 2024; accepted March 13, 2025
*1 \u0007Department of Blood Transfusion and Cell Therapy, University of Yamanashi Hospital, 1110 Shimokato, Chuo, Yamanashi 409-3898 Japan
*2 \u0007Japanese Red Cross Yamanashi Blood Center, 1-6-1 Ikeda, Kofu, Yamanashi 400-0062 Japan
*3 \u0007Department of Nutritional Management, University of Yamanashi Hospital, 1110 Shimokato, Chuo, Yamanashi 409-3898 Japan
*4 Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898 Japan
*5 \u0007Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898 Japan<\/strong><\/span><\/p>\n\n\n\n

Download PDF<\/span><\/a><\/div>\n\n\n\n

ABSTRACT<\/strong><\/h2>\n\n\n\n

We examined the history of food allergy \uff08FA\uff09 in patients at the University of Yamanashi Hospital who were hospitalized from 2019 to 2021 and developed allergic transfusion reactions \uff08ATRs\uff09. One hundred fifty-seven patients developed mild ATRs, among which 22 patients had a history of FA. Out of the 157 patients, 30 patients received red blood cell \uff08RBC\uff09 transfusion, among which 20.0% \uff086\/30\uff09 had FA. Thirty patients received fresh frozen plasma \uff08FFP\uff09 transfusion, and 23.3% \uff087\/30\uff09 of them had FA. Ninety-seven patients received platelet concentrate \uff08PC\uff09 transfusion, and 9.3% \uff089\/97\uff09 of them had FA. The FA history-positive rate was 21.7% \uff0813\/60\uff09 in patients who developed mild ATRs after RBC or FFP transfusion, which was significantly higher than that \uff0811.1%, 4,380\/39,473\uff09 in all patients hospitalized and that in patients without any adverse transfusion reactions \uff083.1%\uff09 during the same periods. We suggest the possibility that allergic food antigens included in blood products might partly \uff08maximally 10%\uff09 be involved in the occurrence of mild ATRs after RBC or FFP transfusion. Despite the higher incidence of ATRs after PC transfusion, the involvement of FA was not demonstrated probably because more multimodal factors are implicated in ATRs after PC transfusion.   <\/p>\n\n\n\n

\u3014Lab Med Int 2025; 4(2): 49-53\u3015<\/p>\n\n\n\n

Key Words<\/strong><\/h3>\n\n\n\n

allergic transfusion reactions, food allergy history, allergic predisposition<\/p>\n\n\n\n

I<\/strong>. Introduction<\/strong><\/h2>\n\n\n\n

Transfusion adverse reactions are classified as hemolytic side effects, non-hemolytic side effects, and infections. Non-hemolytic transfusion reactions are classified as allergic transfusion reaction (ATR), febrile nonhemolytic transfusion reaction (FNHTR), transfusion-related acute lung injury (TRALI), transfusion-associated circulatory overload (TACO), hypotension, bacterial sepsis, and others1\uff09, 2\uff09<\/strong><\/sup>. 
Among them, allergy (allergic transfusion reactions; ATRs) is the most frequent and mild-symptomatic transfusion reaction1\uff09<\/strong><\/sup>. An allergy occurs if the immune response shows excessive reactions to eliminate foreign antigens. However, most of the causes of allergy to transfusions have not been elucidated. The only known cause of allergy to blood transfusions is in patients deficient of plasma proteins (IgA or haptoglobin), who produce antibodies to these proteins due to previous blood transfusions3\uff09, 4\uff09<\/strong><\/sup>. Food allergy (FA) is also an allergy elicited through antigen-specific immunological mechanisms induced by food. 
In this study, we investigated the association between allergy after blood transfusion and a history of food allergy in patients who underwent blood transfusion at the University of Yamanashi Hospital.<\/p>\n\n\n\n

II. Methods and subjects<\/strong><\/h2>\n\n\n\n

This study was judged by the Ethics Committee of the University of Yamanashi School of Medicine as not requiring ethical review. For a period of three years from January 2019 to December 2021, we studied patients who underwent blood transfusion and developed transfusion adverse reactions at the University of Yamanashi Hospital. During this period, 14,146 red blood cell (RBC) products, 7,896 fresh frozen plasma (FFP) products, and 6,595 concentrated platelet (PC) products were transfused to the patients. All blood products including RBC, FFP, and PC were transfused based on Guideline for the use of RBC products5\uff09<\/strong><\/sup>, FFP6\uff09<\/strong><\/sup>, and PC7\uff09<\/strong><\/sup>, respectively. As a result, 247 patients developed transfusion adverse reactions. Some patients developed the adverse reactions following transfusion of more than one product (i.e., FFP, RBCs, and platelets). We observed 157 patients who developed allergy after transfusion of a single product. 
Classification of adverse transfusion reactions was determined by a physician based on the guideline of the Japan Society on Transfusion Medicine and Cell Therapy as shown in Supplemental<\/strong> Table 1<\/strong>8\uff09<\/strong><\/sup>. \u201cAllergic adverse reactions (ATRs)\u201d refer to adverse transfusion reactions with 4)pruritus, 5)flushing, 6)urticaria. When patients are served allergen-free meals during hospitalization, they are assumed as patients with food allergies.  
We compared the FA history of these 157 patients who developed allergy reactions with that of all hospitalized patients (39,473 patients). For this, the statistical method chi-square test was used (p < 0.05 was considered to show a significant difference).
The all-inpatient data including ages, gender, and their afflicted disease were from the hospital statistics of University of Yamanashi Hospital shown in the homepage (https:\/\/www.hosp.yamanashi.ac.jp\/wp-content\/uploads\/2022\/12\/17d3e528c13ac6d071ec4dbf0a9b801d-1.pdf<\/a>).<\/p>\n\n\n\n

III. Results<\/strong><\/h2>\n\n\n\n

Breakdown of adverse blood transfusion reactions<\/strong>
Among 247 patients who developed transfusion reactions, no hemolytic adverse reactions were observed, and all were non-hemolytic. Excluding patients who underwent transfusion of multiple products, 200 patients (339 cases) developed adverse transfusion reactions (Table 1A<\/strong>). Among these 339 cases, 0.44% (62 cases) developed adverse reactions after RBC transfusion, 0.72% (57 cases) after FFP transfusion, and 3.34% (220 cases) after PC transfusion. Furthermore, among the 339 cases (200 patients), 330 cases (193 patients) were mild. Among the mild 330 cases (193 patients), 286 cases (157 patients) were allergic (mild ATRs)(Table 1A<\/strong>).<\/p>\n\n\n\n

Association between FA history and adverse reactions to blood transfusion<\/strong>
Among the 157 patients who developed allergy reactions after transfusion, 14.0% (22\/157) have an FA history. Furthermore, among these 157 patients, 30 patients received RBC transfusion and 20.0% (6\/30) of them had a history of FA. Thirty patients received FFP transfusion, and 23.3% (7\/30) of them had a history of FA. Ninety-seven patients received PC transfusion, and 9.3% (9\/97) of them also had a history of FA (Table 1A<\/strong>). 
During the study period, the total number of hospitalized patients was 39,473, among which 11.1% (4,380\/39,473) had an FA history (Table 1B<\/strong>). Compared with this, the percentage of patients with a history of FA in RBC transfused or FFP transfused patients (21.7%) was significantly higher (p = 0.042). FA history rate of the patients who underwent blood transfusion without any adverse transfusion reactions was also investigated (Table 1B<\/strong>), and was 3.1% (89\/2830), much lower than the FA rate of the ATR patients with FFP\/RBC transfusion (21\/7%) (p = 2.12\u00d710-13<\/sup>). On the other hand, there was no significant difference in the FA history rate between the PC transfused patients and all hospitalized patients.
Table 2<\/strong> shows a list of foods (the number of patients in parentheses) excluded from allergen-free meals during their hospitalization.<\/p>\n\n\n\n

Baseline characteristics<\/strong>
Baseline characteristics of the patients with ATRs and all the hospitalized patients were shown in Supplemental Figures 1 and 2<\/strong>. Age structure in increments of 5 years of the ATR patients (157) and all inpatients from 2019 to 2021 are shown in Supplemental<\/strong> Figure 1A, B<\/strong>. we found no difference of the ratios of 0\u301c4 years old patients between the 2 groups (p = 0.981, proportion z-test with Yates\u2019 continuous correction). Moreover, there is no statistical significance of all the patient age compositions between the 2 groups (p = 0.999, paired T test). Therefore, higher percentage of FA in the ATR patients is not because of higher percentage of infants.    
As for gender, the male ratio was not different between in the ATR group and in the all-inpatient group (p = 0.262, proportion z-test with Yates\u2019 continuous correction) (Supplemental Figure 1C<\/strong>).  
Supplemental Figure 2<\/strong> shows that disease compositions of the 2 groups are different from each other. Sixty-nine % of the ATR patients was malignant neoplasm patients, whereas only 31% in the all-inpatient group. As expected, most of malignant tumor in the ATR group is hematological tumor. This is followed by hematologic disease except for neoplasm, which is included in others due to only a limited percentage in the all inpatient group.<\/p>\n\n\n\n


Table 1A<\/strong>   Types of Adverse Blood Transfusion Reactions<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

*1 Patients who had separate reactions with different blood products were counted as separate patients.
*2 Excluding compound blood product administration RBC; red blood cells, FFP: fresh frozen plasma, PC; platelet concentrates, FA; food allergy<\/p>\n\n\n\n


Table 1B<\/strong>  Percentage of FA patients in patients without adverse transfusion reactions and in all in-patients \uff082019 \u2013 21\uff09<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

IV. Discussion<\/strong><\/h2>\n\n\n\n

Although ATRs are the most frequent transfusion-related adverse reactions, the search for the cause is not usually carried out in mild cases, and thus the mechanism is not fully understood9\uff09<\/sup>. However, previous reports suggest that allergic constitution such as bronchial asthma, hay fever, atopic dermatitis, and food allergy are closely related to the development of ATRs10\uff09-12\uff09<\/strong><\/sup>.
The prevalence of FA in Japan is reported to be 4.0 – 16.7% in infancy, 1.3 – 4.5% in school-age children, and less than 5% after school age13\uff09<\/strong><\/sup>. However, after the school age, infants with FA often find it possible to ingest the food they are allergic to. Ebisawa et al. reported that the cumulative food allergy incidence was 64.5% in 2-year-old children, 80.3% in 5-year-old children, and 90.1% in 10-year-old children based on a survey of 2,954 cases14\uff09<\/strong><\/sup>. On the other hand, the precise percentage of those with a history of FA in the general population is unknown. In this study, by examining the number of patients who were served allergen-free meals, we found that approximately 10% of inpatients at the University of Yamanashi Hospital have a history of FA. 
There is no difference in the infant ratios between the ATR patient and all inpatient groups (Supplemental Figure 1A, B<\/strong>). Therefore, higher percentage of FA in the ATR patients is not because of higher percentage of infants. 
The FA history-positive rate was 3.1% (89\/2830) in patients who did not develop adverse transfusion effects after blood transfusion, which was significantly lower than that in patients who developed ATRs after RBC or FFP transfusion (21.7%, 13\/60)(p = 2.12\u00d710-13<\/sup>). This rate (3.1%) is also significantly lower than the ratio in all patients in (11.1%, 4,380\/39,473) (p = 3.88\u00d710-40<\/sup>). These findings further support that food allergy is at least one of the causes of ATR.
Despite allergen-free meals, if the patient remains sensitized, the allergic reaction may be triggered when the allergen in the food enters the body from blood donors through blood transfusion. However, there have only been a few reports on ATR, probably because of the difficulty in identifying the causative food. Previous case reports identified that blood recipients with a history of allergy to peanuts or shrimp suffered ATR and anaphylaxis due to the transmission via blood products of the antigens ingested by blood donors15\uff09, 16\uff09<\/strong><\/sup>. In this study, we reported that the rate of FA history in patients who developed mild ATRs after receiving RBCs\/FFP was significantly higher than that in other hospitalized patients. We suggest that some (up to 10%) of RBC- and FFP-related ATRs may have been induced by food antigens in the donor serum. On the other hand, the pathogenic mechanisms of PC-related ATRs, which have a very high incidence, are more diverse (e.g., involvement of blood cell-derived cytokines). The involvement of food antigens was relatively low. 
Ebisawa et al. reported that most frequent causative foods for immediate food allergy were hen\u2019s egg (39.0%), cow\u2019s milk (21.8%), and wheat (1.7%)14\uff09<\/strong><\/sup>. However, in this study the most frequent causative foods were grapefruits, shrimps\/crabs, and mackerel (Table 2<\/strong>), which may be due to differences in age groups. 
In conclusion, we found that the FA history-positive rate was 21.7% in patients who developed mild ATRs after RBC\/FFP transfusion, which was significantly higher than that in all hospitalized patients (11.1%) and that in hospitalized patients without any adverse transfusion reactions (3.1%). We suggest the possibility that allergic food antigens included in blood products might partly be involved in the occurrence of mild ATRs, although a large-scale study is required to clarify the role of FA in the development of mild ATRs.<\/p>\n\n\n\n

COI disclosure:<\/strong> The authors declare no conflicts of interest associated with this manuscript.<\/p>\n\n\n\n

Funding source:<\/strong> The authors did not receive support from any organization for the submitted work.
The abstract of this report was presented at the 70th <\/sup>Annual Meeting of the Japanese Association of Blood Transfusion Cell and Therapy (Nagoya International Conference Center, Nagoya, 2022).<\/p>\n\n\n\n

Acknowledgments:<\/strong> The authors thank Momoka Hanagata, Kohei Saito, Hiromi Akai, Naofumi Ito, Yuki Adachi, and Yoichi Yamamoto for their help in the study.<\/p>\n\n\n\n


Table 2<\/strong>  A list of foods excluded from allergen-free meals during the hospitalization \uff08the number of patients\uff09<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

References<\/strong><\/h2>\n\n\n\n
    \n
  1. Yanagisawa R. Preventing adverse reactions in pediatric transfusions using washed platelet concentrate. Pediat Int. 2021; 63\uff084\uff09: 391-403. doi: 10.1111\/ped.14572.PubMed<\/a><\/span><\/li>\n\n\n\n
  2. Moncharmont P. Adverse transfusion reactions in transfused children. Transfus Clin Biol. 2019; 26\uff084\uff09: 329-35. doi: 10.1016\/j.tracli.2019.08.002.PubMed<\/a><\/span><\/li>\n\n\n\n
  3. Robitaille N, Delage G, Long A, et al. Allergic transfusion reactions from blood components donated by IgA-deficient donors with and without anti-IgA: a comparative retrospective study. Vox Sang. 2010; 99\uff082\uff09: 136-41. doi: 10.1111\/j.1423-0410.2010.01326.x.PubMed<\/a><\/span>\n<\/li>\n\n\n\n
  4. Anani W, Triulzi D, Yazer MH, et al. Relative IgA-deficient recipients have an increased risk of severe allergic transfusion reactions. Vox Sang. 2014; 107\uff084\uff09: 389-92. doi: 10.1111\/vox.12192.PubMed<\/a><\/span>\n<\/li>\n\n\n\n
  5. Yonemura Y, Matsumoto M, Inada E, et al. Guideline for the use of red blood cell products based on scientific evidence (revision 2nd edition). Japanese Journal of Transfusion and Cell Therapy. 2018; 64\uff086\uff09: 688-99.J-STAGE<\/a><\/span><\/li>\n\n\n\n
  6. Matsushita T, Hasegawa Y, Tamai Y, et al. Guideline for the use of fresh frozen plasma based on scientific evidence (revised second version). Japanese Journal of Transfusion and Cell Therapy. 2019; 65\uff083\uff09: 525-37.J-STAGE<\/a><\/span><\/li>\n\n\n\n
  7. Takami A, Matsushita T, Ogata M, et al. Guideline for the use of platelet transfusion concentrates based on scientific evidence: update 2019. Japanese Journal of Transfusion and Cell Therapy. 2019; 65\uff083\uff09: 544-61.<\/li>\n\n\n\n
  8. Kato H. Signs and symptoms of transfusion reactions. In: Japanese Society of Blood Transfusion and Cell Therapy Task Force for the preparation of a revised practical guide for management of transfusion reactions, editor. The practical guide for management of transfusion reactions. Version 1.0. Tokyo: The Japan Society of Transfusion Medicine and Cell Therapy. 2014: P.24-8<\/li>\n\n\n\n
  9. Yasui K, Matsuyama N, Takihara Y, et al. New insights into allergic transfusion reactions and their causal relationships, pathogenesis, and prevention. Transfusion. 2020; 60\uff087\uff09: 1590-601. doi: 10.1111\/trf.15845.PubMed<\/a><\/span><\/li>\n\n\n\n
  10. Savage WJ, Hamilton RG, Tobian AAR, et al. Defining risk factors and presentations of allergic reactions to platelet transfusion. J Allergy Clin. Immunol. 2014; 133\uff086\uff09: 1772-5.e9. doi: 10.1016\/j.jaci.2014.03.030.PubMed<\/a><\/span><\/li>\n\n\n\n
  11. Yanagisawa R, Ishimine N, Komori K, et al. Relationship between allergic transfusion reactions and allergic predisposition among pediatric patients with hematological\/oncological disease. Transfusion. 2022; 62\uff085\uff09: 1035-44. doi: 10.1111\/trf.16855.PubMed<\/a><\/span><\/li>\n\n\n\n
  12. Ide Y, Yanagisawa R, Kobayashi J, et al. Relationship between allergic sensitisation-associated single-nucleotide polymorphisms and allergic transfusion reactions and febrile non-haemolytic transfusion reactions in paediatric cases. Blood Transfus. 2022; 20\uff082\uff09: 94-102. doi: 10.2450\/2021.0230-20.PubMed<\/a><\/span><\/li>\n\n\n\n
  13. Matsubara Y, Ae R, Ohya Y, et al. [Estimated number of patients with food allergy in Japan: The present status and issues regarding epidemiological investigation]. Arerugi.   2018; 67\uff086\uff09: 767-73. doi: 10.15036\/arerugi.67.767.PubMed<\/a><\/span><\/li>\n\n\n\n
  14. Ebisawa M, Ito K, Fujisawa T. Japanese guidelines for food allergy 2020. Allergol Int. 2020; 69\uff083\uff09: 370-86. doi: 10.1016\/j.alit.2020.03.004.J-STAGE<\/a><\/span><\/li>\n\n\n\n
  15. Jacobs JFM, Baumert JL, Brons PP, et al. Anaphylaxis from passive transfer of peanut allergen in a blood product. N Engl J Med. 2011; 364\uff0820\uff09: 1981-2. doi: 10.1056\/NEJMc1101692.PubMed<\/a><\/span><\/li>\n\n\n\n
  16. Gao L, Sha Y, Yuan K, et al. Allergic transfusion reaction caused by the shrimp allergen of donor blood: a case report. Transfus Apher Sci. 2014; 50\uff081\uff09: 68-70. doi: 10.1016\/j.transci.2013.09.016.PubMed<\/a><\/span><\/li>\n<\/ol>\n\n\n\n

    Supplemental figure<\/strong><\/h2>\n\n\n\n

    Supplemental Table 1<\/strong>    Adverse transfusion reactions<\/p>\n\n\n\n

    A\uff09Non-hemolytic adverse events
    Symptom items<\/p>\n\n\n\n

      \n
    1. fever<\/li>\n\n\n\n
    2. shivering<\/li>\n\n\n\n
    3. feverish<\/li>\n\n\n\n
    4. pruritus<\/li>\n\n\n\n
    5. flushing<\/li>\n\n\n\n
    6. urticaria<\/li>\n\n\n\n
    7. dyspnea<\/li>\n\n\n\n
    8. nausea, vomiting<\/li>\n\n\n\n
    9. chest, abdominal, and low back pain<\/li>\n\n\n\n
    10. headache<\/li>\n\n\n\n
    11. hypotension<\/li>\n\n\n\n
    12. increase in blood pressure<\/li>\n\n\n\n
    13. tachycardia<\/li>\n\n\n\n
    14. angialgia<\/li>\n\n\n\n
    15. disturbed consciousness<\/li>\n\n\n\n
    16. hematuria<\/li>\n\n\n\n
    17. others
      Severe allergic reactions
      Transfusion-related acute lung injury (TRALI)
      Transfusion-associated circulatory overload (TACO) 
      Post-transfusion graft-versus-host disease (Post-transfusion GVHD)
      Post-transfusion purpura (PTP)<\/li>\n<\/ol>\n\n\n\n

      B)  Hemolytic adverse events
      Acute hemolytic transfusion reaction
      Delayed hemolytic transfusion reaction<\/p>\n\n\n\n

      C) Post-transfusion infection  
      HBV, HCV, HIV, bacteria, others<\/p>\n\n\n\n

      \"\"<\/figure>\n\n\n\n

      Supplemental Figure <\/strong>1  Age and gender of the patient with ATRs and all inpatients from 2019 to 2021<\/p>\n\n\n\n

      Numbers (A) and percentage (B) are shown as age structure in increments of 5 years of ATR patients (excluding duplicates) and all inpatients from 2019 to 2021. (C) Gender of the patients are shown as age structure in increments of 5 years of ATR patients and all inpatients from 2019 to 2021. Data of all inpatients were from the homepage of University of Yamanashi Hospital (https:\/\/www.hosp.yamanashi.ac.jp\/wpcontent\/uploads\/2022\/12\/17d3e528c13ac6d071ec4dbf0a9b801d-1.pdf<\/a>).  ATR; allergic transfusion reactions<\/p>\n\n\n\n

      A)  Disease Composition of Patients with Adverse Blood Transfusion Reactions (2019-21) (%)<\/p>\n\n\n\n

      \"\"<\/figure>\n\n\n\n

      B) Disease Composition of All Inpatients (2019-21) (%)<\/p>\n\n\n\n

      \"\"<\/figure>\n\n\n\n

      Supplemental Figure 2<\/strong>  Disease composition of the patient with ATRs and all inpatients from 2019 – 21<\/p>\n\n\n\n

      Disease composition of ATR patients (A) and all inpatients (B) are shown. Data of all inpatients were from the homepage of University of Yamanashi Hospital (https:\/\/www.hosp.yamanashi.ac.jp\/wpcontent\/uploads\/2022\/12\/17d3e528c13ac6d071ec4dbf0a9b801d-1.pdf<\/a>).  ATR; allergic transfusion reactions<\/p>\n","protected":false},"excerpt":{"rendered":"

       Katsuhiro Takano*1, Kazuha Tobo*2, Hiroshi Nakamura*2, Toshiaki Shirai*1, Takako Kobayashi*3, Yuko Nakaj […]<\/p>\n","protected":false},"author":1,"featured_media":1815,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","footnotes":""},"categories":[151],"tags":[155],"class_list":["post-1650","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-short-communication","tag-lab-med-int-2025-422"],"_links":{"self":[{"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/posts\/1650","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/comments?post=1650"}],"version-history":[{"count":12,"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/posts\/1650\/revisions"}],"predecessor-version":[{"id":1685,"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/posts\/1650\/revisions\/1685"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/media\/1815"}],"wp:attachment":[{"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/media?parent=1650"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/categories?post=1650"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lmi.jp\/articles\/wp-json\/wp\/v2\/tags?post=1650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}